In a word: YES.

Why? The phenomena is simple in theory but complex to explain fully. I'll make an attempt here to do so. We are talking about the difference between vacuum tubes and solid-state devices, e.g. bipolar transistors and semiconductor IC's. Note that I did not include FET devices, which are a form of solid-state device but operate differently than the other solid state devices - I'll cover these later.

The answer lies in the harmonic content that the device [tube/transistor] can pass or generate. What's known is that the human ear finds 'even' harmonics pleasing and 'odd' harmonics annoying or grating, or in the least unmusical. First a word about harmonics. Harmonics, for those who are not versed in wave theory, are simply frequencies which are related to the fundamental frequency being reproduced and are generated in sympathy to the fundamental note. As an example, a note on a piano or guitar string when struck contains a fundamental frequency plus other frequencies that are odd or even multiples of that fundamental note. This is a naturally occurring phenomena, and are often called overtones, and is what give an instrument its characteristic sound. It is important to note that these harmonics are predominately even. If no harmonics were present the note would be a pure sine wave and sound like a single tone.

To illustrate, a 100Hz sound wave, if not pure, may generate harmonics out to the nth order.  How strong and how many of these harmonics are present will determine the harmonic content, or harmonic distortion (THD) as it is characterized (when deemed undesirable). An example: a square wave has 100% harmonic distortion, the fundamental plus all its harmonics are present in equal amounts. In a square wave (e.g. digital) harmonics are very desirable. In fact the more the better. In the analog world and musically speaking, the inverse is true.

What are even and odd harmonics? It just refers to their respective mathematical relationship to the fundamental. Using the same 100Hz example, the 2nd, 4th & 6th harmonics (even) would be 200, 400 and 600Hz respectively, the 3rd, 5th and 7th harmonics (odd) would be 300, 500 and 700Hz, etc. In low distortion equipment (i.e. audio gear) these harmonics will decrease exponentially as the order goes up and the faster the better, resulting in lower THD.

Tubes: there are a couple of important characteristics that separate tubes and solid state devices. First, by nature vacuum tubes are not very fast elements. That's a good thing for music lovers. Being relatively slow, the tube cannot generate huge amounts of harmonics even if it wanted to so they act as a kind of intrinsic filter to our benefit. Second, tubes favor even harmonics and are less inclined toward odd ones.  In fact tubes are rich in second order harmonics and by the time the 3rd shows up, it is greatly reduced by the tubes natural characteristic. This is what is attributed to a tubes classic "warmth" . And lastly tubes are voltage based devices, they amplify voltage instead of current. That I'll save for another time.

Bipolar transistors and IC's are very fast, making them ideal digital devices. They operate in two modes: switch mode, e.g. ON & OFF for making square waves or pulses for the digital world, and linear mode, meaning what comes out is proportional to the signal that is put in and is how they are used in amplifiers (power and preamps). They can and will generate harmonics waaaay out there. They are also rich in odd harmonics which results in the unpleasing or harsh, edgy quality often attributed to them. These devices in linear mode [that is, as they are used in amplifiers] are current amplifiers.

A side note; The first IC's and transistor based opamps that came into being around 1969/1970 sounded awful - very thin and "card boardy". I remember the first recording console delivered to the studio [a very famous one back then] where I was working at the time and had these opamps in it. It sounded really bad. This was at a point in time where the world was changing from discreet transistors to opamps (amplifiers on a chip) in the professional audio equipment world. Also one inch 8 track tape recorders (not the consumer cassette machines) were a big deal too. Anyway I digress.

Finally, earlier I mentioned FET's or field effect transistors. Like tubes they are voltage amplifiers and generate predominately even harmonics, making them a very good substitute for the vacuum tube with the same pleasing musical sound. That is why you see some amp manufactures making a big deal of MOS-FET  and other similar devices in their products.

Hope that helps and makes some sense.