In the early part of the 20th century, the Dead Sea began to attract interest from chemists who deduced that the Sea was a natural deposit of potash and bromine. The Palestine Potash Company was chartered in 1929 (after its founder, Moses Novomeysky, a Jewish engineer from Siberia, worked for the charter for over ten years). The first plant was on the north shore of the Dead Sea at Kalia and produced potash, or potassium chloride, by solar evaporation of the brine. Employing Arabs and Jews, it was an island of peace in turbulent times. The company quickly grew into the largest industrial site in the Middle East and in 1934 built a second plant on the southwest shore, in the Sodom area, south of the 'Lashon' region of the Dead Sea. The Dead Sea Works Ltd. was established in 1952 as a state-owned company to extract potash and other minerals from the Dead Sea.

From the Dead Sea brine, Israel produces (2001) 1.77 million tons potash, 206,000 tons elemental bromine, 44,900 tons caustic soda, 25,000 tons magnesium metal, and sodium chloride. On the Jordanian side of the Dead Sea, Arab Potash (APC), formed in 1956, produces 2.0 million tons of potash annually, as well as sodium chloride and bromine. Both companies use extensive salt evaporation pans that have essentially diked the entire southern end of the Dead Sea for the purpose of producing carnallite, potassium magnesium chloride, which is then processed further to produce potassium chloride. The power plant on the Israeli side allows production of magnesium metal (by a subsidiary, Dead Sea Magnesium Ltd.). The salt evaporation pans are visible from space.