Usually Pixter screens need to be calibrated at one time or another. Often people believe their Pixter is broken and throw them out, but the fix is very simple. The symptom's are as follows:

When you draw on the screen, the tip of the stylus doesn’t line up with where you’re drawing.
When you touch a button or arrow, nothing happens.
When you select a stamper, the stamper next to the one you wanted appears on the screen. 
When you select a tool, you get the tool next to the one selected.

Here’s how you fix it:

Turn the power on. Wait until you see the "Home" screen.
Find the small hole in the back of your Pixter unit above the battery compartment door. That’s the calibration hole.
Insert, push and hold the stylus in the calibration hole. Turn Pixter over so that you can see the screen. When you see two plus signs, remove the stylus from the calibration hole.
First touch the plus sign in the upper left corner with the tip of the stylus.
Then touch the plus sign in the lower right corner with the tip of the stylus.

9 times out of 10 this will fix your Pixter screen. So before you throw your Pixter out, give this simple fix a try!